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KMID : 0357220070190010033
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Journal of Korean Society Physical Therapy
2007 Volume.19 No. 1 p.33 ~ p.44
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The effect of Environmental Enrichment and Peripheral Nerve Electrical Stimulation on Functional Recovery after Brain in rats
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Kim Sa-Youl
Kim Tae-Youl
Oh Myung-Hwa
Kim Young-Eok
Jang Mi-Kyoung
Sim Ki-Cheol
Kim Gye-Yeop
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Abstract
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Purpose: To investigate and analyze effects of environmental enrichment(EE) and nerve stimulation that follows in application times with change of functional recovery(1, 3, 7 and 14 days).
Methods: Focal ischemic brain injury was produced in 100 Sprauge-Dawley rats through middle cerebral artery occlusion(MCAO). Neurobehavioral assessment were selected, such as tilting plane testing, horizontal wire testing, vestibulomotor function testing and complex neuromotor function test, then they were randomly divided into five groups; Group I : Sham group, Group II: MCAO group, Group III: MCAO and ES group, Group IV: MCAO and EE group, Group V: MCAO and EE and ES group.
Results: In neurobehavioral assessment, group V were significantly difference from other groups on between-subject effects.
Conclusions: Our findings suggest that in focal ishemic brain injury, combined environmental enrichment and peripheral nerve electrical stimulation is more improved that the improvement of exercise function recovery than non treatment group.
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KEYWORD
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Focal ishemic brain injury, Environmental enrichment(EE), Electrical stimulation(ES), Function recovery
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